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Once more unto the breach, and with it emerges another opportunity to dissect the rich tapestry of weekend fixtures. Football never sleeps, most notably amid this busiest time of year.
The selections for this weekend's action are detailed below:
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Wolfsburg vs Freiburg
The hosts exploded from the gates with lightning intensity against resurgent Borussia Mönchengladbach last weekend, firing home three strikes inside the first 34 minutes as the home side glided to a comprehensive 3-1 win at Borussia-Park.
Freiburg, by contrast, displayed considerable character after Jobe Bellingham's red card on the hour last weekend, clawing back from behind to salvage a hard-earned point against the challenging Borussia Dortmund.
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The Black Forest club, however, have experienced difficulty on their road trips of late, gathering just two points from the last five games' worth available away from their fortress at Europa-Park Stadion.
SELECTION: Wolfsburg to win either halves at 1.64
Baden-Württemberg Derby
Stuttgart arrested a three-match winless run and find themselves within touching distance of their higher-ranked opponents.
Hoffenheim travel to the MHP Arena riding a wave of momentum. Christian Ilzer's team found the net twice in each half against Championship winners Hamburg in gameweek 14, coasting to a comprehensive 4-1 triumph at the PreZero Arena.
This fixture promises to deliver goals aplenty.
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SELECTION: Both teams to score at 1.43
RB Leipzig vs Bayer Leverkusen
RB Leipzig remained level for only three minutes against Union Berlin after Tidiam Gomis' equaliser last weekend.
That result arrested a three-game unbeaten streak and represented a disappointing outcome to close the gap to Bayern Munich, who were held against Mainz 05.
Bayer Leverkusen, meanwhile, showed no mercy against newly-promoted FC Köln as late efforts from Martin Terrier and Robert Andrich sealed a comfortable 2-0 home victory.
SELECTION: Both teams to score at 1.46
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De Kuip Showdown
Feyenoord arrive to the cauldron of De Kuip looking to respond after a sobering 2-0 reverse away to Ajax in the historic De Klassieker.
Twente travel to Rotterdam with superior momentum and fewer scars. John van den Brom's side have tasted loss just once in their last dozen league matches.
Historical encounters between the sides have consistently delivered goals rather than stalemates, even if the outcomes are often narrow.
VERDICT: Both teams to score at 1.52
South Coast Versus Northeast
Brighton's poor recent run continued at against the Reds as they experienced a third match without victory in succession.
Sunderland's return to the Premier League hit a new pinnacle after they vanquished local foes Newcastle to move within two points of the Champions League positions.
The AMEX showdown constitutes a challenging road trip for Sunderland.
VERDICT: Over 1.5 Goals at 1.27
Gil Vicente vs Rio Ave
Gil Vicente appears to be running out of steam after a remarkable start to the season.
Rio Ave have experienced some difficulties off the pitch, which have manifested onto the playing surface – only one win in their last five encounters.
Saturday's contest may prove an important match for both teams to halt their present trajectory.
SELECTION: Gil Vicente to win either halves at 1.42
Tottenham vs Liverpool
Thomas Frank continues to feel mounting scrutiny after Tottenham turned in another dismal performance at Nottingham Forest to endure a fourth league defeat in seven.
Liverpool are a shadow of the team that claimed the title last season, but two wins and two draws from their last four games represents some sort of progress given how disastrous their campaign has generally been.
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Arne Slot's side have struck 15 goals in their last three top-flight games against Tottenham.
PREDICTION: Both teams to score at 1.56
Southampton vs Coventry
Jovon Makama struck a brace for a troubled Norwich side in gameweek 21 as Southampton were subjected to an disappointing reverse at Carrow Road.
Winger Ephron Mason-Clark was the saviour for Coventry last weekend as his second-half opener turned out to be adequate to earn all three points against Bristol City.
Southampton's backline continues to struggle and Coventry's not always secure, so this encounter ought to deliver attacking entertainment.
SELECTION: Both teams to score at 1.48
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