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Once more unto the breach, and with it emerges another opportunity to dissect the intricate marketplace of weekend fixtures. The season's rhythm intensifies, particularly during this busiest time of year.
The selections for this weekend's action are detailed below:
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Wolfsburg vs Freiburg
Wolfsburg emerged from the traps with lightning intensity against resurgent Borussia Mönchengladbach last weekend, firing home three goals inside the initial 34 minutes as Wolfsburg sailed to a commanding 3-1 victory on the road.
Freiburg, for their part, demonstrated notable fortitude after Jobe Bellingham's red card on the hour last weekend, fighting from behind to secure a valuable point against the formidable Borussia Dortmund.
Christian Streich's charges, however, have experienced difficulty on their travels of late, accumulating a paltry two points from the last five games' worth available away from their fortress at Europa-Park Stadion.
VERDICT: Wolfsburg to win either halves at 1.64
Baden-Württemberg Derby
Stuttgart ended a concerning winless run and sit just one point behind their fifth-placed opponents.
Hoffenheim travel to the MHP Arena in high spirits. Christian Ilzer's team found the net twice in each half against Championship winners Hamburg in gameweek 14, cruising to a commanding 4-1 win on home soil.
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The Stuttgart showdown should provide attacking entertainment.
VERDICT: Both teams to score at 1.43
RB Leipzig vs Bayer Leverkusen
RB Leipzig remained level for a mere three minutes against Union Berlin after Tidiam Gomis' leveller last weekend.
The draw arrested a three-game unbeaten streak and constituted a missed opportunity to reduce the distance to Bayern Munich, who themselves drew against Mainz 05.
Bayer Leverkusen, meanwhile, took no chances against newly-promoted FC Köln as goals after the interval from Martin Terrier and Robert Andrich confirmed a routine 2-0 home victory.
SELECTION: Both teams to score at 1.46
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Eredivisie Heavyweight Clash
Feyenoord head back to home at De Kuip looking to respond after a sobering 2-0 defeat away to Ajax in the storied De Klassieker.
Twente journey to Rotterdam with superior momentum and less baggage. John van den Brom's charges have tasted loss on a single occasion in their last 12 league matches.
Recent meetings between the sides have reliably generated attacking fare, even if final scorelines are often tight.
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VERDICT: Both teams to score at 1.52
AMEX Stadium Contest
Brighton's troubling form extended at Liverpool as they suffered a third fixture without three points in succession.
Sunderland's return to the Premier League achieved a new peak after they vanquished local foes Newcastle to move within two points of the Champions League spots.
This is a difficult away assignment for Sunderland.
PREDICTION: Over 1.5 Goals at 1.27
Gil Vicente vs Rio Ave
Gil Vicente seems to be losing momentum after a remarkable start to the season.
Rio Ave have had considerable troubles off the pitch, which have carried over onto the playing surface – only one win in their last five matches.
Saturday's contest may prove an crucial encounter for both teams to reverse their present trajectory.
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PREDICTION: Gil Vicente to win either halves at 1.42
North London Hosts Merseyside
Thomas Frank continues to feel intense pressure after Tottenham delivered another dreadful performance at Nottingham Forest to endure a fourth league defeat in seven.
Liverpool are far from the team that lifted the title last season, but two wins and two draws from their last four matches represents tentative recovery given how disastrous their campaign has predominantly been.
The Reds have struck 15 goals in their last three Premier League fixtures against Tottenham.
SELECTION: Both teams to score at 1.56
Saints Host The Sky Blues
Jovon Makama struck a brace for a faltering Norwich side in gameweek 21 as Southampton were consigned to an disappointing loss on the road at Carrow Road.
Winger Ephron Mason-Clark was the saviour for Coventry last weekend as his goal after the break was enough to claim all three points against Bristol City.
Southampton's rearguard remains porous and Coventry's not always secure, so this fixture ought to deliver attacking entertainment.
SELECTION: Both teams to score at 1.48
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